99.8% purity White Powder Research Chemicals Etizolam Medical Raw Hormone Eti

Medical Etizolam pharma intermediates Purity 99% Cas 40054-69-1

Basic information of Etizolam

1.Details

• ProName: High quality and low price Etizolam

• CasNo: 40054-69-1

• Molecular Formula: C17H15ClN4S

• Appearance: white powder

• Application: Medical usage

• DeliveryTime: within 2 days after you payment

• PackAge: In bag

• Port: Shanghai

• ProductionCapacity: 100 Kilogram/Month

• Purity: 99.5%min

• Storage: In room

• Transportation: by courier

• LimitNum: 10 Gram

• Related Substances: 0.001%

• Residue on Ignition: 0.001%

• Heavy Metal: 0.001%

• Valid Period: 3 years

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More information about Etizolam

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Etizolam gets the formal and systematic IUPAC name 4-(2-Chlorophenyl)-2-ethyl-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine. It provides a relative molar mass of 342 grams plus an empirical formula of C17H15ClN4S. It can be a psychoactive depressant and anxiolytic in the thienodiazepine class. The thienodiazepines are heterocylic compounds made up of the thiophene ring fused with a diazepine ring.

In vivo etizolam features a high bioavailability of 93 % which is readily absorbed within the alimentary canal. Metabolic rate of the medical treatment is mainly within the liver while using drug obtaining a biological half information on 6.2 hrs as well as the primary metabolite you get one half information on 8.2 hrs. Excretion is simply by the kidney route. Its considered through an average liability for dependence and is administered by dental, rectal and sublingual routes.

Particularly etizolam departs in the benzodiazepine in structre because the benzene ring is substituted with a thiopene and in addition a triazole is fused developing a thienotriazolodiazepine compound. Etizolam may be used just like a medicine and marketed beneath the names Pasaden, Depas, Etizest, Sedekopan, Etilaam and Etizola.

Thienodiazeoines for instance etizolam bind for the same site at GABAa as benzodiazepine. They produce similar effects as benzodiazepines and so are considered almost identical.

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Tolerance, dependence and withdrawal

Abrupt or rapid discontinuation from etizolam, as with benzodiazepines , may result in the appearance

of the benzodiazepine withdrawal syndrome , including rebound insomnia . [10]Neuroleptic malignant

syndrome , a rare event in benzodiazepine withdrawal, has been documented in a case of abrupt

benzodiazepines such as diazepam resulting in a more rapid drug level decrease in blood plasma levels.

In a study that compares the effectiveness of etizolam, alprazolam , and bromazepam for the

treatment of generalized anxiety disorder , all three drugs retained their effectiveness over 2 weeks,

but etizolam became more effective from 2 weeks to 4 weeks, a type of reverse tolerance. [13]

When multiple doses of etizolam, or lorazepam , were administered to rat neurons, lorazepam caused

downregulation of alpha-1 benzodiazepine binding sites (tolerance / dependence), while etizolam caused

an increase in alpha-2 benzodiazepine binding sites (reverse tolerance to anti-anxiety effects). [15]

the anticonvulsant effects of etizolam was observed. [15] Etizolam therefore has a reduced liability to

induce tolerance, and dependence, compared with classic benzodiazepines. [15]

potent hypnotic properties, and is comparable with other short-acting benzodiazepines. Etizolam acts as a

full agonist at the benzodiazepine receptor to produce its range of therapeutic and adverse effects. [18]

According to the Italian PI sheet ^[ citation needed ] , etizolam belongs to a new class of diazepines ,

thienotriazolodiazepines . This new class is easily oxidized , rapidly metabolized , and has a lower risk of

accumulation, even after prolonged treatment. Etizolam has an anxiolytic action about 6 times greater than

that of diazepam . Etizolam produces, especially at higher dosages, a reduction in time taken to fall asleep,

substantial changes in deep sleep ; however, it may reduce REM sleep . In EEG tests of healthy volunteers,

etizolam showed some similar characteristics to tricyclic antidepressants .