Research Chemicals 5F MDMB 2201 Powder Etizolam is TEN TIMES more potent that

Etizolam Research Chemical Powder Etizolam is TEN TIMES more potent that Valium and Diazepam

Product Description

Etizolam
Etizolam (marketed under the brand name Etilaam, Etizola, Sedekopan, Etizest, Pasaden or Depas) is a benzodiazepine analog.[4] The etizolam molecule differs from a benzodiazepine in that the benzene ring has been replaced by a thiophene ring and triazole ring has been fused, making the drug a thienotriazolodiazepine.[5][6] It possesses amnesic, anxiolytic, anticonvulsant, hypnotic, sedative and skeletal muscle relaxant properties.

Indications
Short-term treatment of insomnia[8]
Short-term treatment of anxiety or panic attacks, if a benzodiazepine is required[citation needed].
Side effects
Blepharospasms with long-term use[9]
Very Rare

Erythema annulare centrifugum skin lesions[10]
Tolerance, dependence and withdrawal
Abrupt or rapid discontinuation from etizolam, as with benzodiazepines, may result in the appearance of the benzodiazepine withdrawal syndrome, including rebound insomnia.[11] Neuroleptic malignant syndrome, a rare event in benzodiazepine withdrawal, has been documented in a case of abrupt withdrawal from etizolam.[12] This is particularly relevant given etizolams short half life relative to benzodiazepines such as diazepam resulting in a more rapid drug level decrease in blood plasma levels.[13]

In a study that compared the effectiveness of etizolam, alprazolam, and bromazepam for the treatment of generalized anxiety disorder, all three drugs retained their effectiveness over 2 weeks, but etizolam became more effective from 2 weeks to 4 weeks, a type of reverse tolerance.[14] Administering .5 mg etizolam twice daily did not induce cognitive deficits over 3 weeks when compared to placebo.[15]

When multiple doses of etizolam, or lorazepam, were administered to rat neurons, lorazepam caused downregulation of alpha-1 benzodiazepine binding sites (tolerance/dependence), while etizolam caused an increase in alpha-2 benzodiazepine binding sites (reverse tolerance to anti-anxiety effects).[16] Tolerance to the anticonvulsant effects of lorazepam was observed, but no significant tolerance to the anticonvulsant effects of etizolam was observed.[16] Etizolam therefore has a reduced liability to induce tolerance, and dependence, compared with classic benzodiazepines.

Pharmacology
Etizolam, a thienodiazepine derivative, is absorbed fairly rapidly, with peak plasma levels achieved between 30 minutes and 2 hours. It has a mean elimination half life of about 3.5 hours.[17] Etizolam possesses potent hypnotic properties,[18] and is comparable with other short-acting benzodiazepines.[17] Etizolam acts as a full agonist at the benzodiazepine receptor to produce its range of therapeutic and adverse effects.[19]

According to the Italian P.I. sheet[citation needed], etizolam belongs to a new class of diazepines, thienotriazolodiazepines. This new class is easily oxidized, rapidly metabolized, and has a lower risk of accumulation, even after prolonged treatment. Etizolam has an anxiolytic action about 6 times greater than that of diazepam. Etizolam produces, especially at higher dosages, a reduction in time taken to fall asleep, an increase in total sleep time, and a reduction in the number of awakenings. During tests, there were no substantial changes in deep sleep; however, it may reduce REM sleep. In EEG tests of healthy volunteers, etizolam showed some similar characteristics to tricyclic antidepressants.[3]

Interactions
Itraconazole and fluvoxamine slow down the rate of elimination of etizolam, leading to accumulation of etizolam, therefore increasing its pharmacological effects.[31][32] Carbamazepine speeds up the metabolism of etizolam, resulting in reduced pharmacological effects.[33]

Overdose
See also: Benzodiazepine overdose
Cases of intentional suicide by overdose using etizolam in combination with GABA agonists have been reported.[34][35] Although etizolam has a lower LD50 than certain benzodiazepines, the LD50 is still far beyond the prescribed or recommended dose. Flumazenil, a GABA antagonist agent used to reverse benzodiazepine overdoses, inhibits the effect of etizolam as well as classical benzodiazepines such as diazepam and chlordiazepoxide.[36]

Abuse
See also: Benzodiazepine misuse
Etizolam is a drug of potential abuse. Cases of etizolam dependence have been documented in the medical literature.[37] However, conflicting reports from the World Health Organization, made public in 1991, dispute the abuse claims.[38] Since 1991, cases of etizolam abuse and addiction have substantially increased,[39] due to varying levels of accessibility and cultural popularity.

Company Introduction:

Shandong Shengri Chemical Co., Ltd.

Shandong Shengri Chemical Co., Ltd. is located in Shandong province, China.

Shandong Shengri Chemical Co., Ltd. is an experienced enterprise of manufacturing various kind of research chemicals(cannabinoids and stimulant), steroids, Human Growth Hormone HGH, hyaluronic acid and peptide products.
Shandong Shengri Chemical Co., Ltd. research and development center also offers custom synthesis services.

Price,company and service advantage:

1 Best service, high quality and reasonable price

2. Its customers right to choose the package (EMS, DHL, FedEx, UPS);

3. Its customers right to choose the packing way for his produccts from many recent effective packing ways

4. Specials are possible when clients order is big enough, including the discount policy;

5. Our company promise to deliver clients package to his hands safely, or well cover the total loss and reship your order;

6. Return policy: we promise we will return your money if our product don have effect

Our Advantages:

1.we have over 10 years experience in this aera

2.we can provide competitive price for every customer and guarantee the quality of our goods.

3.we are attention to every customers requirements and make a good relationship with them.

4.we have a long business relationship with many countries, such as canada, mexico, brazil, united kingdom, russia, germany, india, south africa, malta, egypt, armenia, australia, philippines, belgium, netherlands, denmark ect.

If you have any other questions to consult me.please not hesitate to contact me at any time.

1. why choose us

1. rich experience
we specialize in this filed for many years,our steriods and hormones exported to all over the world and established long friendly relations of coroperation with them.

2. great quality,purity and favorable
good quality is one of our biggest secert to success;u can get the best quality and service from us.

3. safest and fastest delivery
we have adequate stock so that we can deliver the products with 24 hours as soon as receiving the payment.fast and discreet shipment will be arranged to pass customs.

4. good package
unique ways to ship 10g to 100kg powders to your destination.we offer melting powder into liquid service and ship the liquid in special bottles.

5. great after-sales service
any questions or problems after receiving the product,pls feel free to contact us.problems would be solved immediately.

2. order guide

Q1: have your product quality been approved by third party lab
A: yes, all products are strictly tested by our qc, confirmed by qa and approved by third party lab in china, usa, canada, germany, uk, italy, france etc. so you will be assured with good quality if you choose us.

Q2: how do you treat quality complaint
A: first of all, our qc department will do strict examination of our export products by hplc, uv, gc , tlc and so on in order to reduce the quality problem to near zero. if there is a real quality problem ,caused by us, we will send you free goods for replacement or refund your loss.

Q3: is there any discount
A: yes, for larger quantity, we always support with better price.

Q4: how long does it take to the goods arrived
A:it is depending on your location,
for small order, please expect 5-7 days by dhl,ups,tnt, fedex, ems.
for mass order, please allow 5-8 days by air, 20-35 days by sea.

Q5 do you have any reshipment policy
A: we have good after-sale service and re-shipment policy if the parcel lose.