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White Powder Research Chemicals Etizolam , Medical Raw Hormone Eti Cas 40054-69
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Linyi shengming chemical products Co., Ltd2020-07-10 09:46:19
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Product Details
Place of Origin: | China | Supply Ability: | 500kg/month | Packaging Details: | 1kg/Aluminum foil bag |
product name: | etizolam | Purity: | 99.9% | Color: | white |
Cas: | 40054-69-1 | Other names: | etizolam,ETI | purpose: | just for research |
Formula: | C17H15ClN4S |
Product Description
Medical Etizolam pharma intermediates Purity 99% Cas 40054-69-1
Basic information of Etizolam
CAS: | 40054-69-1 |
Formula: | C17H15ClN4S |
Molecular weight | 342.07 |
Compound purity: | > 99.7% |
Appearance: | powder |
IUPAC: | 7-(2-Chlorophenyl)-4-ethyl-13-methyl-3-thia-1,8,11,12-tetraazatricyclo[8.3.0.02,6] trideca-2(6),4,7,10,12-pentaene |
capacity | 500kg |
packing | foil bag |
Type of shipping | MS, TNT, FEDEX, DHL, UPS |
Payment terms |
T/T or Western Union or Money Gram or Bitcoin |
1.Details
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ProName: High quality and low price Etizolam
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CasNo: 40054-69-1
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Molecular Formula: C17H15ClN4S
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Appearance: white powder
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Application: Medical usage
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DeliveryTime: within 2 days after you payment
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PackAge: In bag
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Port: Shanghai
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ProductionCapacity: 100 Kilogram/Month
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Purity: 99.5%min
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Storage: In room
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Transportation: by courier
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LimitNum: 10 Gram
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Related Substances: 0.001%
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Residue on Ignition: 0.001%
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Heavy Metal: 0.001%
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Valid Period: 3 years
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Etizolam gets the formal and systematic IUPAC name 4-(2-Chlorophenyl)-2-ethyl-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine. It provides a relative molar mass of 342 grams plus an empirical formula of C17H15ClN4S. It can be a psychoactive depressant and anxiolytic in the thienodiazepine class. The thienodiazepines are heterocylic compounds made up of the thiophene ring fused with a diazepine ring.
In vivo etizolam features a high bioavailability of 93 % which is readily absorbed within the alimentary canal. Metabolic rate of the medical treatment is mainly within the liver while using drug obtaining a biological half information on 6.2 hrs as well as the primary metabolite you get one half information on 8.2 hrs. Excretion is simply by the kidney route. Its considered through an average liability for dependence and is administered by dental, rectal and sublingual routes.
Particularly etizolam departs in the benzodiazepine in structre because the benzene ring is substituted with a thiopene and in addition a triazole is fused developing a thienotriazolodiazepine compound. Etizolam may be used just like a medicine and marketed beneath the names Pasaden, Depas, Etizest, Sedekopan, Etilaam and Etizola.
Thienodiazeoines for instance etizolam bind for the same site at GABAa as benzodiazepine. They produce similar effects as benzodiazepines and so are considered almost identical.
Tolerance, dependence and withdrawal
Abrupt or rapid discontinuation from etizolam, as with benzodiazepines , may result in the appearance
of the benzodiazepine withdrawal syndrome , including rebound insomnia . [10]Neuroleptic malignant
syndrome , a rare event in benzodiazepine withdrawal, has been documented in a case of abrupt
withdrawal from etizolam. This is particularly relevant given etizolams short half life relative to
benzodiazepines such as diazepam resulting in a more rapid drug level decrease in blood plasma levels.
In a study that compares the effectiveness of etizolam, alprazolam , and bromazepam for the
treatment of generalized anxiety disorder , all three drugs retained their effectiveness over 2 weeks,
but etizolam became more effective from 2 weeks to 4 weeks, a type of reverse tolerance. [13]
Administering .5 mg etizolam twice daily did not induce cognitive deficits over 3 weeks when
compared to placebo
When multiple doses of etizolam, or lorazepam , were administered to rat neurons, lorazepam caused
downregulation of alpha-1 benzodiazepine binding sites (tolerance / dependence), while etizolam caused
an increase in alpha-2 benzodiazepine binding sites (reverse tolerance to anti-anxiety effects). [15]
Tolerance to the anticonvulsant effects of lorazepam was observed, but no significant tolerance to
the anticonvulsant effects of etizolam was observed. [15] Etizolam therefore has a reduced liability to
induce tolerance, and dependence, compared with classic benzodiazepines. [15]
Pharmacology
Etizolam, a thienodiazepine derivative, is immediately absorbed with peak plasma levels
It has a mean elimination half life of about 3.5 hours. Etizolam possesses
potent hypnotic properties, and is comparable with other short-acting benzodiazepines. Etizolam acts as a
full agonist at the benzodiazepine receptor to produce its range of therapeutic and adverse effects. [18]
According to the Italian PI sheet [ citation needed ] , etizolam belongs to a new class of diazepines ,
thienotriazolodiazepines . This new class is easily oxidized , rapidly metabolized , and has a lower risk of
accumulation, even after prolonged treatment. Etizolam has an anxiolytic action about 6 times greater than
an increase in total sleep time, and a reduction in the number of awakenings. During tests, there were no
substantial changes in deep sleep ; however, it may reduce REM sleep . In EEG tests of healthy volunteers,
etizolam showed some similar characteristics to tricyclic antidepressants .
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