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CAS 40054-69-1 Pure Research Chemicals white powder Etizolam Claybank Color SGS
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Product Details
| Place of Origin: | China | Supply Ability: | 500kg/month | Packaging Details: | 1kg/Aluminum foil bag |
| product name: | etizolam | Purity: | 99.9% | Color: | claybank |
| Cas: | 40054-69-1 | Other names: | etizolam,ETI | purpose: | just for research |
Product Description
Basic info.:
| Product Name | Etizolam |
| Purity | 99% |
| Appearance | Powder |
| CAS NO | 40054-69-1 |
| Delivery Time | Within 1-3 days after payment |
| Package | Aluminum foil bag or according to your requirement |
| Production Capacity | 500 Kilograms/Month |
| Application | For lab or chemical research |
| Transportation | EMS,DHL,TNT,FEDEX,UPS or as customs requirements |
| Limit Num | 5 Grams |
| Port | Shanghai Port or any other ports in China |
| Storage | Kept in a cool, dry and ventilated place |
Packing: Aluminum foil bag or as clients requirements
Delivery time: Within 3-5 working days after payment confirmation
Shipping: HK EMS,EUB,UPS,Fedex,DHL,TNT
Payment Terms: Western Union,Money Gram,Bitcoins
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Etizolam (marketed under the brand name Etilaam, Etizola, Sedekopan, Etizest, Pasaden or Depas) is
a benzodiazepine analog. The etizolam molecule differs from a benzodiazepine in that the benzene
ring has been replaced by a thiophene ring and triazole ring has been fused, making the drug a
thienotriazolodiazepine. It possesses amnesic, anxiolytic, anticonvulsant, hypnotic, sedative and
skeletal muscle relaxant properties.
Tolerance, dependence and withdrawal
Abrupt or rapid discontinuation from etizolam, as with benzodiazepines, may result in the appearance
of the benzodiazepine withdrawal syndrome, including rebound insomnia.[10] Neuroleptic malignant
syndrome, a rare event in benzodiazepine withdrawal, has been documented in a case of abrupt
withdrawal from etizolam. This is particularly relevant given etizolams short half life relative to
benzodiazepines such as diazepam resulting in a more rapid drug level decrease in blood plasma levels.
In a study that compared the effectiveness of etizolam, alprazolam, and bromazepam for the
treatment of generalized anxiety disorder, all three drugs retained their effectiveness over 2 weeks,
but etizolam became more effective from 2 weeks to 4 weeks, a type of reverse tolerance.[13]
Administering .5 mg etizolam twice daily did not induce cognitive deficits over 3 weeks when
compared to placebo.
When multiple doses of etizolam, or lorazepam, were administered to rat neurons, lorazepam caused
downregulation of alpha-1 benzodiazepine binding sites (tolerance/dependence), while etizolam caused
an increase in alpha-2 benzodiazepine binding sites (reverse tolerance to anti-anxiety effects).[15]
Tolerance to the anticonvulsant effects of lorazepam was observed, but no significant tolerance to
the anticonvulsant effects of etizolam was observed.[15] Etizolam therefore has a reduced liability to
induce tolerance, and dependence, compared with classic benzodiazepines.[15]
Pharmacology
Etizolam, a thienodiazepine derivative, is absorbed fairly rapidly, with peak plasma levels achieved between
30 minutes and 2 hours. It has a mean elimination half life of about 3.5 hours. Etizolam possesses
potent hypnotic properties,and is comparable with other short-acting benzodiazepines.Etizolam acts as a
full agonist at the benzodiazepine receptor to produce its range of therapeutic and adverse effects.[18]
According to the Italian P.I. sheet[citation needed], etizolam belongs to a new class of diazepines,
thienotriazolodiazepines. This new class is easily oxidized, rapidly metabolized, and has a lower risk of
accumulation, even after prolonged treatment. Etizolam has an anxiolytic action about 6 times greater than
that of diazepam. Etizolam produces, especially at higher dosages, a reduction in time taken to fall asleep,
an increase in total sleep time, and a reduction in the number of awakenings. During tests, there were no
substantial changes in deep sleep; however, it may reduce REM sleep. In EEG tests of healthy volunteers,
etizolam showed some similar characteristics to tricyclic antidepressants.
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