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Strong Cannabinoids Etizolam Pharmaceutical Intermediates research chemical CAS
- Etizolam
40054-69-1
- SGT151
- 10g
- Negotiable
- 1-2days
- Western Union, T/T, MoneyGram
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Linyi shengming chemical products Co., Ltd2020-07-10 09:46:19
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Product Details
Place of Origin: | china | Supply Ability: | 500kg per month | Packaging Details: | safe and discreet packaging |
other name: | Etizolam | cas: | 40054-69-1 | Colour: | white |
shipping: | DHL EMS | Appearance: | Powder | Formula: | C16H13ClN2O |
Product Description
Etizolam Intermediate Pharmaceutical Products C17H15ClN4S Formula SGS Certification
Product name: Etizolam |
CAS: 40054-69-1 |
Appearance:white crystalline powder |
Purity: 99.8% |
Usage: For research purpose |
Packing: Aluminum foil bag or as clients requirements
Delivery time: Within 3-5 working days after payment confirmation
Shipping: HK EMS,EUB,UPS,Fedex,DHL,TNT
Payment Terms: Western Union,Money Gram,Bitcoins.
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Price
Price Condition :FOB
Delivery Port :shenzhen
Packaging & Delivery
Delivery Lead Time :1-2days
Minimum Order :10g
Supply Ability :1000kg/month
Etizolam (marketed under the brand name Etilaam, Etizola, Sedekopan, Etizest, Pasaden or Depas) is
a benzodiazepine analog. The etizolam molecule differs from a benzodiazepine in that the benzene
ring has been replaced by a thiophene ring and triazole ring has been fused, making the drug a
thienotriazolodiazepine. It possesses amnesic, anxiolytic, anticonvulsant, hypnotic, sedative and
skeletal muscle relaxant properties.
Tolerance, dependence and withdrawal
Abrupt or rapid discontinuation from etizolam, as with benzodiazepines, may result in the appearance
of the benzodiazepine withdrawal syndrome, including rebound insomnia.[10] Neuroleptic malignant
syndrome, a rare event in benzodiazepine withdrawal, has been documented in a case of abrupt
withdrawal from etizolam. This is particularly relevant given etizolams short half life relative to
benzodiazepines such as diazepam resulting in a more rapid drug level decrease in blood plasma levels.
In a study that compared the effectiveness of etizolam, alprazolam, and bromazepam for the
treatment of generalized anxiety disorder, all three drugs retained their effectiveness over 2 weeks,
but etizolam became more effective from 2 weeks to 4 weeks, a type of reverse tolerance.[13]
Administering .5 mg etizolam twice daily did not induce cognitive deficits over 3 weeks when
compared to placebo.
When multiple doses of etizolam, or lorazepam, were administered to rat neurons, lorazepam caused
downregulation of alpha-1 benzodiazepine binding sites (tolerance/dependence), while etizolam caused
an increase in alpha-2 benzodiazepine binding sites (reverse tolerance to anti-anxiety effects).[15]
Tolerance to the anticonvulsant effects of lorazepam was observed, but no significant tolerance to
the anticonvulsant effects of etizolam was observed.[15] Etizolam therefore has a reduced liability to
induce tolerance, and dependence, compared with classic benzodiazepines.[15]
Pharmacology
Etizolam, a thienodiazepine derivative, is absorbed fairly rapidly, with peak plasma levels achieved between 30 minutes and 2 hours. It has a mean elimination half life of about 3.5 hours. Etizolam possessespotent hypnotic properties,and is comparable with other short-actingbenzodiazepines.Etizolam acts as afull agonist at the benzodiazepine receptor to produce its range of therapeutic and adverse effects.[18]According to the Italian P.I. sheet[citation needed], etizolam belongs to a new class of diazepines,thienotriazolodiazepines. This new class is easily oxidized, rapidly metabolized, and has a lower risk of accumulation, even after prolonged treatment. Etizolam has an anxiolytic action about 6 times greater than that of diazepam. Etizolam produces, especially at higher dosages, a reduction in time taken to fall asleep,an increase in total sleep time, and a reduction in the number of awakenings. During tests, there were no substantial changes in deep sleep; however, it may reduce REM sleep. In EEG tests of healthy volunteers,etizolam showed some similar characteristics to tricyclic antidepressants.
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