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Home>Products>Pure Research Chemicals>Strong Cannabinoids Etizolam Pharmaceutical Intermediates research chemical CAS

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  • Strong Cannabinoids Etizolam Pharmaceutical Intermediates research chemical CAS
  • Strong Cannabinoids Etizolam Pharmaceutical Intermediates research chemical CAS
  • Strong Cannabinoids Etizolam Pharmaceutical Intermediates research chemical CAS
  • Strong Cannabinoids Etizolam Pharmaceutical Intermediates research chemical CAS
  • Strong Cannabinoids Etizolam Pharmaceutical Intermediates research chemical CAS
  • Strong Cannabinoids Etizolam Pharmaceutical Intermediates research chemical CAS

Strong Cannabinoids Etizolam Pharmaceutical Intermediates research chemical CAS

  • Etizolam
  • 40054-69-1

  • SGT151
  • 10g
  • Negotiable
  • 1-2days
  • Western Union, T/T, MoneyGram
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Linyi shengming chemical products Co., Ltd

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  • Linyi shengming chemical products Co., Ltd2020-07-10 09:46:19
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Product Details

Place of Origin: china Supply Ability: 500kg per month Packaging Details: safe and discreet packaging
other name: Etizolam cas: 40054-69-1 Colour: white
shipping: DHL EMS Appearance: Powder Formula: C16H13ClN2O

Product Description

Etizolam Intermediate Pharmaceutical Products C17H15ClN4S Formula SGS Certification

Product name: Etizolam

CAS: 40054-69-1

Appearance:white crystalline powder

Purity: 99.8%

Usage: For research purpose

Packing: Aluminum foil bag or as clients requirements

Delivery time: Within 3-5 working days after payment confirmation

Shipping: HK EMS,EUB,UPS,Fedex,DHL,TNT

Payment Terms: Western Union,Money Gram,Bitcoins.


If you need detailed information or have any question, please feel free to contact me, I will give you reply as

soon as possible.

Price

Price Condition :FOB

Delivery Port :shenzhen

Packaging & Delivery

Delivery Lead Time :1-2days

Minimum Order :10g

Supply Ability :1000kg/month

Etizolam (marketed under the brand name Etilaam, Etizola, Sedekopan, Etizest, Pasaden or Depas) is

a benzodiazepine analog. The etizolam molecule differs from a benzodiazepine in that the benzene

ring has been replaced by a thiophene ring and triazole ring has been fused, making the drug a

thienotriazolodiazepine. It possesses amnesic, anxiolytic, anticonvulsant, hypnotic, sedative and

skeletal muscle relaxant properties.

Tolerance, dependence and withdrawal

Abrupt or rapid discontinuation from etizolam, as with benzodiazepines, may result in the appearance

of the benzodiazepine withdrawal syndrome, including rebound insomnia.[10] Neuroleptic malignant

syndrome, a rare event in benzodiazepine withdrawal, has been documented in a case of abrupt

withdrawal from etizolam. This is particularly relevant given etizolams short half life relative to

benzodiazepines such as diazepam resulting in a more rapid drug level decrease in blood plasma levels.

In a study that compared the effectiveness of etizolam, alprazolam, and bromazepam for the

treatment of generalized anxiety disorder, all three drugs retained their effectiveness over 2 weeks,

but etizolam became more effective from 2 weeks to 4 weeks, a type of reverse tolerance.[13]

Administering .5 mg etizolam twice daily did not induce cognitive deficits over 3 weeks when

compared to placebo.

When multiple doses of etizolam, or lorazepam, were administered to rat neurons, lorazepam caused

downregulation of alpha-1 benzodiazepine binding sites (tolerance/dependence), while etizolam caused

an increase in alpha-2 benzodiazepine binding sites (reverse tolerance to anti-anxiety effects).[15]

Tolerance to the anticonvulsant effects of lorazepam was observed, but no significant tolerance to

the anticonvulsant effects of etizolam was observed.[15] Etizolam therefore has a reduced liability to

induce tolerance, and dependence, compared with classic benzodiazepines.[15]

Pharmacology

Etizolam, a thienodiazepine derivative, is absorbed fairly rapidly, with peak plasma levels achieved between 30 minutes and 2 hours. It has a mean elimination half life of about 3.5 hours. Etizolam possessespotent hypnotic properties,and is comparable with other short-actingbenzodiazepines.Etizolam acts as afull agonist at the benzodiazepine receptor to produce its range of therapeutic and adverse effects.[18]According to the Italian P.I. sheet[citation needed], etizolam belongs to a new class of diazepines,thienotriazolodiazepines. This new class is easily oxidized, rapidly metabolized, and has a lower risk of accumulation, even after prolonged treatment. Etizolam has an anxiolytic action about 6 times greater than that of diazepam. Etizolam produces, especially at higher dosages, a reduction in time taken to fall asleep,an increase in total sleep time, and a reduction in the number of awakenings. During tests, there were no substantial changes in deep sleep; however, it may reduce REM sleep. In EEG tests of healthy volunteers,etizolam showed some similar characteristics to tricyclic antidepressants.

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