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Description:

AROMASIN Tablets for oral administration contain 25 mg of exemestane, an irreversible, steroidal aromatase inactivator. Exemestane is chemically described as 6-methylenandrosta-1,4-diene-3,17-dione.The active ingredient is a white to slightly yellow crystalline powder with a molecular weight of 296.41.Exemestane is freely soluble in N, N-dimethylformamide, soluble in methanol, and practically insoluble in water.

Usages:

This medication is used to treat certain types of breast cancer (such as hormone-receptor-positive breast cancer) in women after menopause. Exemestane is also used to help prevent the cancer from returning. Some breast cancers are made to grow faster by a natural hormone called estrogen.Exemestane decreases the amount of estrogen the body makes and helps to slow or reverse the growth of these breast cancers.

Mechanism Of Action:

Exemestane is an irreversible, steroidal aromatase inactivator, structurally related to the natural substrate androstenedione. It acts as a false substrate for the aromatase enzyme, and is processed to an intermediate that binds irreversibly to the active site of the enzyme, causing its inactivation, an effect also known as "suicide inhibition.".

Exemestane significantly lowers circulating estrogen concentrations in postmenopausal women, but has no detectable effect on adrenal biosynthesis of corticosteroids or aldosterone. Exemestane has no effect on other enzymes involved in the steroidogenic pathway up to a concentration at least 600 times higher than that inhibiting the aromatase enzyme.

Treatment by Condition Related to exemestane:

Hormone Receptor Positive Postmenopausal Early Breast Cancer After Adjuvant Tamoxifen Medications;

Breast Cancer that has Spread to Another Part of the Body Medications;Prevention of Breast Cancer Medications;Advanced Breast Cancer Progression Post-Antiestrogen Therapy Medications

How to use exemestane?

Take this medication by mouth, usually once daily with food (after a meal), or as directed by your doctor.

Dosage is based on your medical condition, response to treatment, and other medications you may be taking. Be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).Use this medication regularly to get the most benefit from it. To help you remember, take it at the same time each day.

Side Effects:

Hot flashes, hair loss, joint/bone/muscle pain, tiredness, unusual sweating, nausea, diarrhea, dizziness, and trouble sleeping may occur.