Eptifibatide indicated to decrease the rate of a combined endpoint of death or

Eptifibatide indicated to decrease the rate of a combined endpoint of death or new myocardial infarction

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Acute Coronary Syndrome (ACS)
Eptifibatide Injection is indicated to decrease the rate of a combined endpoint of death or new myocardial infarction (MI) in patients with ACS (unstable angina [UA]/non-ST-elevation myocardial infarction [NSTEMI]), including patients who are to be managed medically and those undergoing percutaneous coronary intervention (PCI).

Eptifibatide Injection Dosage and Administration
Before infusion of Eptifibatide Injection, the following laboratory tests should be performed to identify pre-existing hemostatic abnormalities: hematocrit or hemoglobin, platelet count, serum creatinine, and PT/aPTT. In patients undergoing PCI, the activated clotting time (ACT) should also be measured.

The activated partial thromboplastin time (aPTT) should be maintained between 50 and 70 seconds unless PCI is to be performed. In patients treated with heparin, bleeding can be minimized by close monitoring of the aPTT and ACT.

Important Administration Instructions
Inspect Eptifibatide Injection for particulate matter and discoloration prior to administration, whenever solution and container permit.
May administer Eptifibatide Injection in the same intravenous line as alteplase, atropine, dobutamine, heparin, lidocaine, meperidine, metoprolol, midazolam, morphine, nitroglycerin, or verapamil. Do not administer Eptifibatide Injection through the same intravenous line as furosemide.
May administer Eptifibatide Injection in the same IV line with 0.9% NaCl or 0.9% NaCl/5% dextrose. With either vehicle, the infusion may also contain up to 60 mEq/L of potassium chloride.
Withdraw the bolus dose(s) of Eptifibatide Injection from the 10-mL vial into a syringe. Administer the bolus dose(s) by IV push.
Immediately following the bolus dose administration, initiate a continuous infusion of Eptifibatide Injection. When using an intravenous infusion pump, administer Eptifibatide Injection undiluted directly from the 100-mL vial. Spike the 100-mL vial with a vented infusion set. Center the spike within the circle on the stopper top.
Discard any unused portion left in the vial.

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