BETAINE ANHYDROUS metabolism of a chemical homocysteine Dry mouth Angelman

BETAINE ANHYDROUS metabolism of a chemical homocysteine Dry mouth Angelman syndrome
 
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Betaine anhydrous is a chemical that occurs naturally in the body. It can also be found in foods such as beets, spinach, cereals, seafood, and wine.

Betaine anhydrous is approved by the U.S. Food and Drug Administration (FDA) for treatment of high urine levels of a chemical called homocysteine (homocystinuria) in people with certain inherited disorders. High homocysteine levels are associated with heart disease, weak bones (osteoporosis), skeletal problems, and eye lens problems.

Betaine anhydrous supplements are most commonly used for reducing blood homocysteine levels and trying to improve athletic performance.

How does it work?
Betaine anhydrous helps in the metabolism of a chemical called homocysteine. Homocysteine is involved in the normal function of many different parts of the body, including blood, bones, eyes, heart, muscles, nerves, and the brain. Betaine anhydrous prevents the buildup of homocysteine in the blood. Levels of homocysteine are very high in some people who have problems with its metabolism.

High homocysteine levels in the urine (homocystinuria). Taking betaine anhydrous lowers homocysteine levels in the urine. Betaine anhydrous is FDA approved for treating this condition in both children and adults.
Possibly Effective for
Dry mouth. Using betaine anhydrous in a toothpaste seems to reduce symptoms of dry mouth. Also, using mouthwash containing betaine anhydrous, xylitol, and sodium fluoride seems to improve dry mouth symptoms.
High homocysteine levels in the blood (hyperhomocysteinemia). Research shows that taking betaine anhydrous can decrease homocysteine levels in the blood of some people. However, it is not clear if this also decreases the risk of heart disease. Taking betaine along with folic acid doesn reduce blood homocysteine levels better than taking folic acid alone.
Possibly Ineffective for
Genetic disorder that causes intellectual disability (Angelman syndrome). Taking betaine anhydrous does not seem to prevent seizures or improve mental function in children with Angelman syndrome.
Insufficient Evidence for
Noncancerous tumors in the colon and rectum (colorectal adenomas). Early research has found that higher dietary intake of betaine anhydrous is not linked with a reduced risk of colon and rectum tumors.
Depression. Early research shows that taking betaine anhydrous along with s-adenosyl-L-methionine (SAMe) improves symptoms of depression in more people than does taking the antidepressant amitriptyline.
Exercise performance. Some research suggests that betaine anhydrous can improve certain aspects of exercise performance, including body composition and strength, in men who participate in strength training. However, betaine anhydrous does not seem to improve strength in untrained men.
Acid reflux. Early research suggests that taking betaine anhydrous, along with melatonin, L-tryptophan, vitamin B6, folic acid, vitamin B12, and methionine daily can reduce symptoms of acid reflux.
Hepatitis C. Early research shows that taking betaine anhydrous (Cystadane) plus S-adenosyl-L-methionine along with hepatitis C medications can reduce the amount of active virus in people with hepatitis C who did not respond to treatment with hepatitis C medications alone. However, this effect does not appear to last long-term in most people.
Liver disease not due to alcohol use (nonalcoholic steatohepatitis, NASH). Developing research has found that betaine anhydrous might improve liver disease in people with NASH.
Sunburn. Early research has found that applying a specific betaine anhydrous-containing cream for one month before exposure to sunlight reduces sunburn. However, applying this cream only 20 minutes before exposure does not have any benefit.
Nervous system disorder called Rett syndrome. Early research shows that taking a combination of folate and betaine anhydrous daily for 12 months does not improve growth, development, or function in girls with Rett syndrome.
Weight loss. In one small study, adding betaine anhydrous to a low-calorie diet did not produce extra weight loss in obese adults.
Other conditions.
More evidence is needed to rate the effectiveness of betaine anhydrous for these uses.

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